Article

TIM3 <sup>+</sup> Tumor Associated M2 Macrophages Impair Antitumor T Cell Immunity and Promote Gastric Cancer Progression and Peritoneal Metastasis

2026-04-17

Abstract excerpt

Peritoneal metastases (PM) are the leading cause of cancer-related death in gastric cancer (GC) patients with survival typically < 9 months. Here, we demonstrate that TIM3 and its ligands are increased along the GC continuum and associated with poor survival. Integrated omics analyses and functional studies revealed highly enriched TIM3 in CD163 + tumor associated M2 immunosuppressive macrophages significantly pr...

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Literature Corpus work: 2f70980e-77e2-595b-a0d4-a4437dc7f14b
DOI: 10.64898/2026.04.15.716939

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