Article

Chchd10 or Chchd2 are not Required for Human Motor Neuron Differentiation <i>In Vitro</i> but Modify Synaptic Transcriptomes

2019-11-01

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial intermembrane space proteins CHCHD2 and CHCHD10 have roles in diseases affecting motor neurons such as amyotrophic lateral sclerosis, spinal muscular atrophy and axonal neuropathy and in Parkinson’s disease, and form a complex of unknown function. Here we address the importance of these two proteins in human motor neurons. We show that gene edited human induced pluripotent stem cel...

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Literature Corpus work: 2961b783-f14e-531f-8bc6-ef3e98423e2f
DOI: 10.1101/828376

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