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Article

CRISPR/Cas9-mediated mutations in both a cAMP response element and an ETS-binding site suppress FLT1 gene expression.

Experimental cell research - 1 Mar 2023

Sasagawa Tadashi, Nagamatsu Takeshi, Shibuya Masabumi

Abstract excerpt

The Fms-like tyrosine kinase-1 (FLT1) gene is expressed in various types of cells, including vascular endothelial cells and placental trophoblasts, and regulates angiogenesis, inflammation, and pregnancy. However, the basal transcriptional machinery of FLT1 is still not well understood. In this study, we first examined FLT1 promoter activity in three different types of cells, that is, trophoblast-derived cells,...

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PMID: 36720378
DOI: 10.1016/j.yexcr.2023.113500

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CRISPR/Cas9-mediated mutations in both a cAMP response element and an ETS-binding site suppress FLT1 gene expression.PMID 36720378Read ↗

CRISPR/Cas9-mediated mutations in both a cAMP response element and an ETS-binding site suppress FLT1 gene expressionSemantic proximity Read ↗

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