Article

Detecting TYMS Tandem Repeat Polymorphism by the PSSD Method Based on Next-generation Sequencing

2020-05-05

Abstract excerpt

Background: Thymidylate Synthase (TS) is an important target for folic acid inhibitors such as pemetrexed, which has considerable effects on the first-line treatment, second-line treatment and maintenance therapy for patients with late-stage Non-Small Cell Lung Cancer (NSCLC). Therefore, detecting mutations in the TYMS gene encoding TS is critical in clinical applications. With the development of Next-Generation S...

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Literature Corpus work: 2f0fad6a-0976-53af-81ff-58e498efecb3
DOI: 10.2174/1574893615999200505074805

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