Article

ARPE-19 Epithelial Cells Fail To Initiate Type-I Interferon Signaling in Response to Human Cytomegalovirus Infection

2024-08-01

Abstract excerpt

ARPE-19 cells are a commonly used epithelial model for studying human cytomegalovirus (HCMV) infection. We recently found that ARPE-19 cells assume a mesenchymal phenotype when maintained at low confluency and that ARPE-19 cells resemble mesenchymal fibroblasts rather than epithelial cells in HCMV infection assays. Here, using comparative proteomics analysis, we find that subconfluent ARPE-19 cells are also defici...

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Literature Corpus work: 2ef23afc-eb31-5b23-9fcb-64a5b667d27f
DOI: 10.1101/2024.08.01.606090

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