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Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology

2025-01-15

Abstract excerpt

Autoimmune regulator (AIRE), a transcription factor expressed by medullary thymic epithelial cells, is required for shaping the self-antigen tolerant T cell receptor repertoire. Humans with mutations in AIRE suffer from Autoimmune Polyglandular Syndrome Type 1 (APS-1). Among many symptoms, men with APS-1 commonly experience testicular insufficiency and infertility, but the mechanisms causing infertility are unkno...

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Literature Corpus work
2eba0172-f783-5d09-ac4c-bcdba4cf837b
DOI
10.1101/2025.01.11.632558
Open publication

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Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiologyDOI 10.1101/2025.01.11.632558
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