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Article

Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence.

Frontiers in immunology - 1 Jan 2021

Perniola Roberto, Fierabracci Alessandra, Falorni Alberto

Abstract excerpt

The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator (AIRE) gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage to multimolecular complexes involved in the initiation and post-initiation events of tissue-specific...

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Identifiers

PMID: 33717087
DOI: 10.3389/fimmu.2021.606860
PMCID: PMC7953157

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