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Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology

23 Apr 2025

Abstract excerpt

Autoimmune regulator (AIRE), a transcriptional regulator expressed by medullary thymic epithelial cells, is required for shaping the self-antigen tolerant T cell receptor repertoire. In humans, AIRE mutations caues autoimmune polyglandular syndrome type 1. Among other symptoms, men with autoimmune polyglandular syndrome type 1 commonly experience testicular insufficiency and infertility, but the mechanisms...

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PMID: 40267393
DOI: 10.1093/jimmun/vkaf054

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