Article

Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

2023-08-15

Abstract excerpt

<h4>Background</h4> The development of diverse spatial profiling technologies has provided an unprecedented insight into molecular mechanisms driving cancer pathogenesis. Here, we conducted the first integrated cross-species assessment of spatial transcriptomics and spatial metabolomics alterations associated with progression of intraductal papillary mucinous neoplasms (IPMN), bona fide cystic precursors of panc...

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Literature Corpus work: 2e8764cc-e7f2-5fb3-b73f-4deae7907c1c
DOI: 10.1101/2023.08.14.553002

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