Article

Structure–function analyses of a keratin heterotypic complex identify specific keratin regions involved in intermediate filament assembly

2019-10-29

Abstract excerpt

<h4>SUMMARY</h4> Intermediate filaments (IFs) provide vital mechanical support in a broad array of cell types. Interference with this role causes cell fragility and accounts for a large number of human diseases. Gaining an understanding IF structure is paramount to understanding their function and designing therapeutic agents for relevant diseases. Here, we report the 2.6 Å resolution crystal structure of a compl...

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Literature Corpus work: 2e72e63e-f3d9-5cb5-90ec-16acb6b95d90
DOI: 10.1101/821090

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