Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly.

doi:10.1016/j.str.2020.01.002

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Article

Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly.

Structure (London, England : 1993) - 3 Mar 2020

Lee Chang-Hun, Kim Min-Sung, Li Shuang, Leahy Daniel J, Coulombe Pierre A

Abstract excerpt

Intermediate filaments (IFs) provide vital mechanical support in a broad array of cell types. Interference with this role causes cell fragility and accounts for a large number of human diseases. Gaining an understanding of the structure of IFs is paramount to understanding their function and designing therapeutic agents for relevant diseases. Here, we report the 2.6-Å resolution crystal structure of a complex of...

Topics

Animals
Crystallography, X-Ray
Humans
Intermediate Filaments
Keratin-14
Keratin-5
Mice
Models, Molecular
Mutagenesis, Site-Directed
Mutation
NIH 3T3 Cells
Protein Domains
Protein Multimerization
Protein Structure, Secondary

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Identifiers

PMID: 31995743
DOI: 10.1016/j.str.2020.01.002
PMCID: PMC7058483

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