Article

Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

2021-05-14

Abstract excerpt

Keratin intermediate filaments are an essential and major component of the cytoskeleton in epithelial cells. They form a stable yet dynamic filamentous network extending from the nucleus to the cell periphery. Keratin filaments provide cellular resistance to mechanical stresses, ensure cell and tissue integrity in addition to regulatory functions. Mutations in keratin genes are related to a variety of epithelial t...

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Literature Corpus work: 54141c90-82c9-5a9d-97fd-f86d80db9d09
DOI: 10.1101/2021.05.12.442145

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