Article

miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers

2025-12-15

Abstract excerpt

Although individual microRNAs (miRNAs) can have tumorigenic or tumor-suppressive properties, their overall role in cancer remains controversial. Here, we show that cancer tissues and cell lines are characterized by preferential accumulation of the high-molecular-weight miRNA-induced silencing complex (HMWR), the functionally active form of the effector complex responsible for miRNA-mediated gene repression. Experi...

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Literature Corpus work: 2e47d8a0-a770-53b2-bd47-b932f2fdf145
DOI: 10.64898/2025.12.12.693984

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