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Article

High sensitivity dia-PASEF proteomics with DIA-NN and FragPipe

2021-03-09

Abstract excerpt

The dia-PASEF technology exploits ion mobility separation for high-sensitivity analysis of complex proteomes. Here, we demonstrate neural network-based processing of the ion mobility data, which we implement in the DIA-NN software suite. Using spectral libraries generated with the MSFragger-based FragPipe computational platform, the DIA-NN analysis of dia-PASEF raw data increases the proteomic depth by up to 69% c...

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Identifiers and source

Literature Corpus work
2e3f4515-2a48-5c88-8ca3-a10278aae436
DOI
10.1101/2021.03.08.434385
Open publication

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High sensitivity dia-PASEF proteomics with DIA-NN and FragPipeDOI 10.1101/2021.03.08.434385
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