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Molecular Mechanisms of Drug Resistance in Clear Cell Renal Cell Carcinoma

10 May 2025

Abstract excerpt

Renal cell carcinoma (RCC) accounts for about 3% of all human tumors. Alterations of oxygen, lipids, iron, and energy metabolism are involved in carcinogenesis, development, and expansion. Thirty percent of patients affected by clear cell renal cell carcinoma (ccRCC) will develop relapses or distance metastases (mRCC), dramatically reducing their life expectancy. Current first-line therapies for mRCC patients are...

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PMID: 40427113
DOI: 10.3390/cancers17101613

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