Article

Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential

2022-03-27

Abstract excerpt

<h4>SUMMARY</h4> Current approaches to stage chronic liver diseases have limited utility to directly predict liver cancer risk. Here, we employed single nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and chronically injured pre-malignant livers using two distinct mouse models. Analysis of 40,748 hepatic nuclei unraveled a previously uncharacterized disease-associated h...

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Literature Corpus work: ba60b88c-3f74-5869-84e8-21b27bd5248c
DOI: 10.1101/2022.03.25.485695

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