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Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS2-N501Y <sub>MA30</sub> strain of SARS-CoV-2

2021-12-08

Abstract excerpt

The Omicron SARS-CoV-2 variant has been designated a variant of concern because its spike protein is heavily mutated. In particular, Omicron spike is mutated at 5 positions (K417, N440, E484, Q493 and N501) that have been associated with escape from neutralizing antibodies induced by either infection with or immunization against the early Washington strain of SARS-CoV-2. The mouse-adapted strain of SARS-CoV-2, SAR...

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Literature Corpus work: 2de324f7-affc-57fe-977b-4fcc27d0d1f5
DOI: 10.1101/2021.12.06.471483

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Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS2-N501Y <sub>MA30</sub> strain of SARS-CoV-2DOI 10.1101/2021.12.06.471483Read

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