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Article

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

22 Jun 2021

Abstract excerpt

subgenus. Using chimeric spike designs, we demonstrate protection against challenge from SARS-CoV, SARS-CoV-2, SARS-CoV-2 B.1.351, bat CoV (Bt-CoV) RsSHC014, and a heterologous Bt-CoV WIV-1 in vulnerable aged mice. Chimeric spike messenger RNAs (mRNAs) induced high levels of broadly protective neutralizing antibodies against high-risk Sarbecoviruses. By contrast, SARS-CoV-2 mRNA vaccination not only showed a...

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PMID: 34214046
DOI: 10.1126/science.abi4506

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