Article

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation

2023-02-01

Abstract excerpt

Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human diseases including Kaposi’s sarcoma (KS), a leading cause of cancer in Africa and in patients with AIDS. KS tumor cells harbor KSHV predominantly in a latent form, while typically <5% contain lytic replicating virus. Because both latent and lytic stages likely contribute to cancer initiation and progression, continued dissection of host regulators...

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Literature Corpus work: 84653b7d-ecb1-5703-bf3b-bdb370fb5381
DOI: 10.1101/2023.02.01.526589

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