Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N 6 -Adenosine Methylation To Promote Lytic Replication

Abstract excerpt

ABSTRACT N 6 -adenosine methylation (m 6 A) is the most common posttranscriptional RNA modification in mammalian cells. We found that most transcripts encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome undergo m 6 A modification. The levels of m 6 A-modified mRNAs increased substantially upon stimulation for lytic replication. The blockage of m 6 A inhibited splicing of the pre-mRNA encoding the...

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