Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

2 Dec 2021

Abstract excerpt

In herpesvirus replicating cells, host cell gene transcription is frequently down-regulated because important transcriptional apparatuses are appropriated by viral transcription factors. Here, we show a small peptide derived from the Kaposi's sarcoma-associated herpesvirus transactivator (K-Rta) sequence, which attenuates cellular MYC expression, reduces cell proliferation, and selectively kills cancer cell lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to interferon and immune responses
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34857874
DOI: 10.1038/s42003-021-02853-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growthPMID 34857874Read ↗

KSHV transactivator-derived small peptide traps coactivators to attenuate MYC function and kills leukemia and lymphomaSemantic proximity Read ↗

Analysis of the ubiquitin-modified proteome identifies novel host factors in Kaposi’s sarcoma herpesvirus lytic reactivationSemantic proximity Read ↗

Oncogenic Mechanisms of Kaposi's Sarcoma‐Associated Herpesvirus on Cell Metabolism and Cell TransformationSemantic proximity Read ↗

Strategies to target the cancer driver MYC in tumor cellsSemantic proximity Read ↗

Inhibition of KAP1 Enhances Hypoxia-Induced Kaposi's Sarcoma-Associated Herpesvirus Reactivation through RBP-JκSemantic proximity Read ↗

Peptide tiling across viral proteomes identifies modular regulators of stress-induced cell deathSemantic proximity Read ↗

KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivationSemantic proximity Read ↗

The cellular and KSHV A-to-I RNA editome in primary effusion lymphoma and its role in the viral lifecycleSemantic proximity Read ↗

Suberoyl bis-hydroxamic acid reactivates Kaposi’s sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cellsSemantic proximity Read ↗

Inhibition of KDM5A/B promotes antitumor innate immune responses in HHV-8/KSHV-positive B-cell lymphomasSemantic proximity Read ↗

Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N 6 -Adenosine Methylation To Promote Lytic ReplicationSemantic proximity Read ↗

Lactylation of NAT10 promotes N4‐acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.