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Adult choline supplementation in a Down syndrome model reduces co-morbidities and improves cognition

2024-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Down syndrome (DS) is the most common cause of early-onset Alzheimer’s disease (AD). Dietary choline has been proposed as a modifiable factor to improve cognitive and pathological outcomes of AD, especially as many do not reach adequate daily intake levels. Perinatal choline supplementation (Ch+) in the Ts65Dn mouse model of DS protects offspring against AD-relevant pathology and improves cognit...

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Literature Corpus work
2dc003bc-e7d3-5ed2-8488-8c8a0226feda
DOI
10.1101/2024.09.26.615088
Open publication

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Adult choline supplementation in a Down syndrome model reduces co-morbidities and improves cognitionDOI 10.1101/2024.09.26.615088
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