Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adiponectin Modulation by Genotype and Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease

5 Jul 2021

Abstract excerpt

Down syndrome (DS) is a genetic disorder caused by the triplication of human chromosome 21, which results in neurological and physiological pathologies. These deficits increase during aging and are exacerbated by cognitive decline and increase of Alzheimer's disease (AD) neuropathology. A nontoxic, noninvasive treatment, maternal choline supplementation (MCS) attenuates cognitive decline in mouse models of DS and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Down syndrome and intellectual disability research
Share to GDF15 and Related Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34279477
DOI: 10.3390/jcm10132994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adiponectin Modulation by Genotype and Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s DiseasePMID 34279477Read ↗

Adult choline supplementation in a Down syndrome model reduces co-morbidities and improves cognitionSemantic proximity Read ↗

CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementationSemantic proximity Read ↗

Long‐term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's diseaseSemantic proximity Read ↗

Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and DementiaSemantic proximity Read ↗

Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in a 6-month old Mouse Model of Down Syndrome and Alzheimer’s DiseaseSemantic proximity Read ↗

Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omicsSemantic proximity Read ↗

Standardized Pipeline for Metabolism and Cognition in GO-DS21 Mouse Model: Investigating Down Syndrome Comorbidities.Semantic proximity Read ↗

Aging with Down Syndrome—Where Are We Now and Where Are We Going?Semantic proximity Read ↗

Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn Model of Down Syndrome and Alzheimer’s DiseaseSemantic proximity Read ↗

Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologySemantic proximity Read ↗

Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine modelSemantic proximity Read ↗

Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.