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Article

Mendelian randomization reveals causal relationships between cytokines and male reproductive diseases.

Journal of reproductive immunology - 1 Jun 2025

Ding Jie

Abstract excerpt

This study aims to explore the causal links between cytokines and four male reproductive disorders, namely abnormal spermatozoa (AS), male infertility, erectile dysfunction (ED), and hyperplasia of prostate (HP), employing a two-sample Mendelian randomization (MR) approach. Genetic associations with male reproductive diseases were derived from the IEU OpenGWAS project, with cytokine data from two GWASs focused on...

Read the complete abstract on PubMed

Topics

Male
Humans
Mendelian Randomization Analysis
Cytokines
Infertility, Male
Genome-Wide Association Study
Spermatozoa

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Erectile Dysfunction

Genetic Predisposition to Disease

Prostatic Hyperplasia

Source

Identifiers

PMID: 40023096
DOI: 10.1016/j.jri.2025.104465

Genes

HP
MIP

Provenance

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