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Article

Causal associations between 1400 circulating metabolites and spontaneous abortion: A bidirectional 2-sample Mendelian randomization study.

Medicine - 21 Nov 2025

Zhou Xuan, Fang Yu-Xuan, Zhang Da-Wei, Ma Li-Ya, Yao Man-Man

Abstract excerpt

Spontaneous abortion (SA) affects approximately 10% to 15% of clinically recognized pregnancies. The potential causal role of metabolic disturbances in SA remains poorly defined. We performed a bidirectional 2-sample Mendelian randomization (MR) analysis to evaluate causal associations between 1400 plasma metabolites and SA. Genetic instruments for metabolites were obtained from a genome-wide association study of...

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Identifiers

PMID: 41305730
DOI: 10.1097/MD.0000000000045981
PMCID: PMC12643647

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