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Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis

2023-06-19

Abstract excerpt

Contezolid is a new oxazolidinone with in vitro and in vivo activity against Mycobacterium tuberculosis comparable to that of linezolid. Pre-clinical and clinical safety studies suggest it may be less toxic than linezolid, making contezolid a potential candidate to replace linezolid in treatment of drug-resistant tuberculosis. We evaluated the dose-ranging activity of contezolid, alone and in combination with b...

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Identifiers and source

Literature Corpus work
e1fc9323-73c7-5e72-b700-a9c5d386f40f
DOI
10.1101/2023.06.18.545492
Open publication

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Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosisDOI 10.1101/2023.06.18.545492
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