Article

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

2023-09-13

Abstract excerpt

For cystic fibrosis (CF) patients, a lung targeted gene therapy would significantly alleviate pulmonary complications associated with morbidity and mortality. However, mucus in the airways and cell entry pose huge delivery barriers for local gene therapy. Here, we used phage display technology to select for and identify mucus- and cell-penetrating peptides against primary human bronchial epithelial cells (pHBECs)...

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Literature Corpus work: 2cf9dbfb-c926-5b86-a6d3-7174c0077f60
DOI: 10.1101/2023.09.13.557559

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