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Intratumor heterogeneity and cell secretome promote chemotherapy resistance and progression of colorectal cancer

5 May 2023

Abstract excerpt

The major underlying cause for the high mortality rate in colorectal cancer (CRC) relies on its drug resistance, to which intratumor heterogeneity (ITH) contributes substantially. CRC tumors have been reported to comprise heterogeneous populations of cancer cells that can be grouped into 4 consensus molecular subtypes (CMS). However, the impact of inter-cellular interaction between these cellular states on the...

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PMID: 37142595
DOI: 10.1038/s41419-023-05806-z

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