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Article

Isoniazid resistance in <i>Mycobacterium tuberculosis</i> is a heterogeneous phenotype comprised of overlapping MIC distributions with different underlying resistance mechanisms

2019-01-20

Abstract excerpt

MIC testing using the BACTEC 960 MGIT system of 70 phylogenetically diverse, isoniazid-resistant clinical strains of Mycobacterium tuberculosis revealed a complex pattern of overlapping MIC distributions. Whole-genome sequencing could explain most of the level of resistance observed. The MIC distribution of strains with only inhA promoter mutations was split by the current concentration that is endorsed by the C...

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Literature Corpus work
2c9a4e66-fab1-5b9c-871f-fe839ed09a13
DOI
10.1101/524157
Open publication

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Isoniazid resistance in <i>Mycobacterium tuberculosis</i> is a heterogeneous phenotype comprised of overlapping MIC distributions with different underlying resistance mechanismsDOI 10.1101/524157
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