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Article

Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease.

Stem cell reports - 13 Dec 2022

Ma Baihui, Li Tianjiao, Li Wenke, Yang Hang, Zeng Qixian, Pan Zihang, Wang Kai, Chen Qianlong, Xiong Changming, Zhou Zhou

Abstract excerpt

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension characterized by the preferential remodeling of the pulmonary venules. Hereditary PVOD is caused by biallelic variants of the EIF2AK4 gene. Three PVOD patients who carried the compound heterozygous variants of EIF2AK4 and two healthy controls were recruited and induced pluripotent stem cells (iPSCs) were generated from human...

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Identifiers

PMID: 36400028
DOI: 10.1016/j.stemcr.2022.10.014
PMCID: PMC9768576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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