Article

High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD phenotypes in human lung fibroblasts

2022-03-29

Abstract excerpt

Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative treatments. Considering the environmental cause of COPD (e.g., cigarette smoke) and disease phenotypes, including stem-cell senescence and impaired differentiation, we hypothesized that COPD will be associated with altered epigenetic signaling in lung cells. We generated genome-wide DNA methylation maps at single CpG resoluti...

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Literature Corpus work: 2c863f56-1375-5cc1-ba8b-bf6842799c67
DOI: 10.1101/2022.03.28.486023

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