Article
Epigenetics in lung fibrosis: from pathobiology to treatment perspective.
Current opinion in pulmonary medicine - 1 Sept 2015
Helling Britney A, Yang Ivana V
Abstract excerpt
PURPOSE OF REVIEW: Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options and extensive gene expression changes identified in the lung parenchyma. Multiple lines of evidence suggest that epigenetic factors contribute to dysregulation of gene expression in IPF lung. Most importantly, risk factors that predispose to IPF - age, sex, cigarette smoke, and genetic variants - all influence...
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