Article

Functional analysis of a common BAG3 allele associated with protection from heart failure

2021-10-06

Abstract excerpt

Multiple genetic association studies have correlated a common allelic block linked to the BAG3 gene with a decreased incidence of heart failure, but the molecular mechanism for such protection remains elusive. One of the variants in this allele block is coding, changing cysteine to arginine at position 151 of BAG3 (rs2234962-BAG3 C151R ). Here, we use induced pluripotent stem cells (iPSC) to test if the BAG3 C15...

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Literature Corpus work: 2c65b473-9762-5a49-9d90-96f77fd41be6
DOI: 10.1101/2021.10.06.463213

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