Article
Functional analysis of a common BAG3 allele associated with protection from heart failure.
Nature cardiovascular research - 1 Jul 2023
Perez-Bermejo Juan A, Judge Luke M, Jensen Christina L, Wu Kenneth, Watry Hannah L, Truong Annie, Ho Jaclyn J, Carter Matthew, Runyon Wendy V, Kaake Robyn M, Pulido Ernst H, Mandegar Mohammad A, Swaney Danielle L, So Po-Lin, Krogan Nevan J, Conklin Bruce R
Abstract excerpt
Multiple genetic association studies have correlated a common allelic block linked to the BAG3 gene with a decreased incidence of heart failure, but the molecular mechanism remains elusive. In this study, we used induced pluripotent stem cells to test if the only coding variant in this allele block, BAG3C151R, alters protein and cellular function in human cardiomyocytes. Quantitative protein interaction analysis...
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