Article

Pro108Ser mutant of SARS-CoV-2 3CL<sup>pro</sup> reduces the enzymatic activity and ameliorates COVID-19 severity in Japan

2020-11-24

Abstract excerpt

SARS-CoV-2 genome accumulates point mutations constantly. However, whether non-synonymous mutations affect COVID-19 severity through altering viral protein function remains unknown. SARS-CoV-2 genome sequencing revealed that the number of non-synonymous mutations correlated inversely with COVID-19 severity in Tokyo Metropolitan area. Phylogenic tree analyses identified two predominant groups which were differentia...

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Literature Corpus work: 2c39e080-f65e-5c6f-9688-afbaeef6a67d
DOI: 10.1101/2020.11.24.20235952

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Pro108Ser mutant of SARS-CoV-2 3CL<sup>pro</sup> reduces the enzymatic activity and ameliorates COVID-19 severity in JapanDOI 10.1101/2020.11.24.20235952Read

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