Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site.

doi:10.1080/22221751.2020.1781551

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Article

Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site.

Emerging microbes & infections - 1 Dec 2020

Jin Xi, Xu Kangli, Jiang Penglei, Lian Jiangshan, Hao Shaorui, Yao Hangping, Jia Hongyu, Zhang Yimin, Zheng Lin, Zheng Nuoheng, Chen Dong, Yao Jinmei, Hu Jianhua, Gao Jianguo, Wen Liang, Shen Jian, Ren Yue, Yu Guodong, Wang Xiaoyan, Lu Yingfeng, Yu Xiaopeng, Yu Liang, Xiang Dairong, Wu Nanping, Lu Xiangyun, Cheng Linfang, Liu Fumin, Wu Haibo, Jin Changzhong, Yang Xiaofeng, Qian Pengxu, Qiu Yunqing, Sheng Jifang, Liang Tingbo, Li Lanjuan, Yang Yida

Abstract excerpt

The mutations in the SARS-CoV-2 virus genome during COVID-19 dissemination are unclear. In 788 COVID-19 patients from Zhejiang province, we observed decreased rate of severe/critical cases compared with patients in Wuhan. For mechanisms exploration, we isolated one strain of SARS-CoV-2 (ZJ01) from a mild COVID-19 patient. Thirty-five specific gene mutations were identified. Phylogenetic and relative synonymous...

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Identifiers

PMID: 32543348
DOI: 10.1080/22221751.2020.1781551
PMCID: PMC7473176

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