Article

Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

2021-02-05

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a serious global public health threat. The 3C-like protease (3CLpro) is a virus protease encoded by SARS-CoV-2, which is essential for virus replication. We have previously reported a series of small molecule 3CLpro inhibitors effective for inhibiting replication of human coronaviruses including SARS-CoV-2 in cell culture and in...

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Literature Corpus work: 5736c246-0706-5ee9-a891-b12c1f81f545
DOI: 10.1101/2021.02.05.429937

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