Article

Pro108Ser mutant of SARS-CoV-2 3CL <sup>pro</sup> Reduces the Enzymatic Activity and Ameliorates COVID-19 Severity in Japan

2020-12-30

Abstract excerpt

Background: It is well known that SARS-CoV-2 genome accumulates point mutations constantly. However, whether non-synonymous mutations affect COVID-19 severity through altering viral protein function remains unknown.<br><br>Methods: We performed SARS-CoV-2 genome sequencing in 90 patients with COVID-19 admitted at Keio University Hospital in Tokyo Metropolitan area between March and August 2020. Viral haplotypes we...

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Literature Corpus work: ff960808-b03d-5419-b731-6973a98a265b
DOI: 10.2139/ssrn.3757398

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