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Chimeric Antigen Receptors Transmit Co-stimulatory Domain Dependent Piconewton Forces to their Target

2025-10-23

Abstract excerpt

Chimeric antigen receptor (CAR) T cells promote tumor-specific cytotoxicity through engagement of a recombinant, synthetic receptor with target ligands expressed on cancer cells. Native T cells are mechanically active, both transmitting and sensing forces exceeding 19 piconewtons (pN) via transmembrane receptors, including the T cell receptor (TCR). Emerging evidence implicates mechanoactivity in CAR T cell biolog...

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Identifiers and source

Literature Corpus work
2c358d37-8aa4-51fb-ae0b-c7c4d8c0dd19
DOI
10.1101/2025.10.22.683904
Open publication

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Chimeric Antigen Receptors Transmit Co-stimulatory Domain Dependent Piconewton Forces to their TargetDOI 10.1101/2025.10.22.683904
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