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Article

Abnormal Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Partially Mimicked Development of TSC2 Neurological Abnormalities.

Stem cell reports - 11 Apr 2017

Li Yaqin, Cao Jiqing, Chen Menglong, Li Jing, Sun Yiming, Zhang Yu, Zhu Yuling, Wang Liang, Zhang Cheng

Abstract excerpt

Tuberous sclerosis complex (TSC) is a disease featuring devastating and therapeutically challenging neurological abnormalities. However, there is a lack of specific neural progenitor cell models for TSC. Here, the pathology of TSC was studied using primitive neural stem cells (pNSCs) from a patient presenting a c.1444-2A>C mutation in TSC2. We found that TSC2 pNSCs had higher proliferative activity and increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28344003
DOI: 10.1016/j.stemcr.2017.02.020
PMCID: PMC5390135

Genes

TSC2
PAX6

Provenance

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