Article
Crystal structure of the human B-form low molecular weight phosphotyrosyl phosphatase at 1.6-A resolution.
The Journal of biological chemistry - 10 Mar 2006
Zabell Adam P R, Schroff Alfred D, Bain Bornadata Evans, Van Etten Robert L, Wiest Olaf, Stauffacher Cynthia V
Abstract excerpt
The crystal structure of HPTP-B, a human isoenzyme of the low molecular weight phosphotyrosyl phosphatase (LMW PTPase) is reported here at a resolution of 1.6 A. This high resolution structure of the second human LMW PTPase isoenzyme provides the opportunity to examine the structural basis of different substrate and inhibitor/activator responses. The crystal packing of HPTP-B positions a normally surface-exposed...
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