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Human regnases are evolutionarily diversified antiviral restriction factors targeting viral RNA

2026-07-09

Abstract excerpt

<h4>ABSTRACT</h4> The regnase family of endoribonucleases regulates immune gene expression through degradation of cellular mRNAs. Regnase-1 is known to also target viral RNA, but whether antiviral activity is a conserved property of all human regnases remains unknown. Here, we systematically compare the antiviral properties of all four human regnases. Regnases-1–4 expression inhibited HIV-1, HIV-2, MLV, RSV and h...

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Literature Corpus work
2b4b6cc4-3fd1-5dd0-930a-0260bf5e70df
DOI
10.64898/2026.07.06.736706
Open publication

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Human regnases are evolutionarily diversified antiviral restriction factors targeting viral RNADOI 10.64898/2026.07.06.736706
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