Article

Patient-derived xenografts and organoids model therapy response in prostate cancer

2020-03-18

Abstract excerpt

Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe a novel androgen-dependent PCa patient-derived xenograft (PDX) model from treatment-naïve, soft tissue metastasis (PNPCa). RNA and whole-exome sequencing of the PDX tissue and organoids confirmed transcriptomic and genomic similarity to primary t...

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Literature Corpus work: 2b2d81ca-0d0d-5598-b489-7c93fc305221
DOI: 10.1101/2020.03.17.994350

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