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Article

The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.

Nature structural & molecular biology - 1 Dec 2020

Titus Erron W, Deiter Frederick H, Shi Chenxu, Wojciak Julianne, Scheinman Melvin, Jura Natalia, Deo Rahul C

Abstract excerpt

Mutations in the calcium-binding protein calsequestrin cause the highly lethal familial arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In vivo, calsequestrin multimerizes into filaments, but there is not yet an atomic-resolution structure of a calsequestrin filament. We report a crystal structure of a human cardiac calsequestrin filament with supporting mutational analysis and in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphic Catecholaminergic Ventricular Tachycardia

Share to Protein Conformation, alpha-Helical

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Share to Tachycardia, Ventricular

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Identifiers

PMID: 33046906
DOI: 10.1038/s41594-020-0510-9
PMCID: PMC7718342

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