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Article

Phylogenetic and biochemical analysis of calsequestrin structure and association of its variants with cardiac disorders.

Scientific reports - 22 Oct 2020

Wang Qian, Paskevicius Tautvydas, Filbert Alexander, Qin Wenying, Kim Hyeong Jin, Chen Xing-Zhen, Tang Jingfeng, Dacks Joel B, Agellon Luis B, Michalak Marek

Abstract excerpt

Calsequestrin is among the most abundant proteins in muscle sarcoplasmic reticulum and displays a high capacity but a low affinity for Ca2+ binding. In mammals, calsequestrin is encoded by two genes, CASQ1 and CASQ2, which are expressed almost exclusively in skeletal and cardiac muscles, respectively. Phylogenetic analysis indicates that calsequestrin is an ancient gene in metazoans, and that the duplication of...

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Phylogeny
Amino Acid Sequence
Calcium
Calcium Signaling
Calsequestrin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Sequence Homology, Amino Acid

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Identifiers

PMID: 33093545
DOI: 10.1038/s41598-020-75097-3
PMCID: PMC7582152

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