Article

Desmin Mutations Disrupt Filament Elongation and Drive Polymorphic Aggregation

2026-07-28

Abstract excerpt

In muscle cells, desmin intermediate filaments form a cytoskeletal network that maintains the structural integrity and mechanical coupling of myofibrils. Dominant missense mutations in desmin cause myopathies characterized by intracellular protein aggregation. To explore the process of aggregate formation, we investigate the assembly kinetics of wild-type desmin and four disease-associated variants (N342D, L345P,...

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Literature Corpus work: 2610a362-7659-5bf6-8f23-86586180c3d2
DOI: 10.64898/2026.07.22.740046

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