Article
Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy.
PloS one - 1 Jan 2012
Ochoa Maria C, Fioravanti Jessica, Duitman Erwin H, Medina-Echeverz Jose, Palazon Asis, Arina Ainhoa, Dubrot Juan, Alfaro Carlos, Morales-Kastresana Aizea, Murillo Oihana, Hervas-Stubbs Sandra, Prieto Jesus, Berraondo Pedro, Melero Ignacio
Abstract excerpt
Apolipoprotein A-I (Apo A-I) is a major component of high density lipoproteins (HDL) that transport cholesterol in circulation. We have constructed an expression plasmid encoding a chimeric molecule encompassing interleukin-15 (IL-15) and Apo A-I (pApo-hIL15) that was tested by hydrodynamic injections into mice and was co-administered with a plasmid encoding the sushi domain of IL-15Rα (pSushi) in order to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.