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Convergent within-host evolution alters key virulence factors in a <i>Klebsiella pneumoniae</i> clone during a large hospital outbreak

2024-02-07

Abstract excerpt

Bacterial pathogens adapt to host niches because of within-host selective pressures, and this evolutionary process provides valuable insights into host-pathogen interactions. However, genetic changes underlying adaptive phenotypes are difficult to identify from data generated by genome-wide association studies of unrelated bacterial clones. Here, we followed the evolution of a single Klebsiella pneumoniae clone i...

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Literature Corpus work
2a85d604-b4a2-57d5-abc0-9c3817ccd444
DOI
10.1101/2024.02.06.577356
Open publication

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Convergent within-host evolution alters key virulence factors in a <i>Klebsiella pneumoniae</i> clone during a large hospital outbreakDOI 10.1101/2024.02.06.577356
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