Rapid evolution of Klebsiella pneumoniae biofilms in vitro delineates adaptive changes selected during infection.

Abstract excerpt

Biofilm formation facilitates infection by the opportunistic pathogen Klebsiella pneumoniae, primarily via indwelling medical devices. Here, we explore the adaptive evolution of classical pathotype K. pneumoniae in surface-attached biofilms through experimental evolution that mimics catheter-associated infections. We observe rapid convergent evolution that alters or abolishes capsule production, modifies the...

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