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N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

27 Oct 2023

Abstract excerpt

Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochemical analyses uncover that both the ubiquitin ligase complex UBR4-KCMF1 and the acetyltransferase NatC recognize...

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PMID: 37891180
DOI: 10.1038/s41467-023-42342-y

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